Endosulfan and Endocrine Disruption:
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چکیده
منابع مشابه
Endosulfan-Induced Biomarkers in Japanese Rice Fish (Oryzias latipes) Analyzed by SELDI-TOF-MS
The objective of this study was to find and validate estrogen-related biomarkers from plasma proteins in Oryzias latipes after exposure to an estrogen disrupting compound, α-endosulfan. The acute toxicity of α-endosulfan on O. latipes after 96 h of exposure was 13.72, 16.18, and 22.18 μg L(-1) for the LC10, LC20, and LC50 values, respectively. To confirm estrogenic disturbance by α-endosulfan, ...
متن کاملToxicity of cadmium, endosulfan, and atrazine in adrenal steroidogenic cells of two amphibian species, Xenopus laevis and Rana catesbeiana.
The effects of cadmium, endosulfan, and atrazine on corticosterone secretion and viability of adrenal cells of African clawed frog (Xenopus laevis) and bullfrog (Rana catesbeiana) were assessed in vitro using a new bioassay. The bioassay relies on stimulation with adrenocorticotropic hormone (ACTH), the endogenous secretagogue for corticosterone secretion, and with dibutyryl cyclic adenosine mo...
متن کاملComparative Toxicity of Endosulfan and Fipronil Insecticides: Utilizing In Vivo and In Vitro Data
Background: Endosulfan, an organochlorine compound, and fipronil, a phenylpyrazole, are insecticides with a common mechanism of toxicity. They interfere with Clinflux by binding to the gamma-aminobutyric acid receptor (GABAAR) and blocking the inhibitory actions of GABAA. In vivo they cause neurotoxicity, hepatotoxicity, developmental toxicity, and can alter endocrine and immune systems. The th...
متن کاملAn assessment of the developmental, reproductive, and neurotoxicity of endosulfan.
BACKGROUND Endosulfan has been used for over 50 years. Although most analogs have been discontinued, endosulfan has less environmental persistence. Nevertheless, pressure groups are lobbying for a worldwide ban. The reasons are: possible rodent male reproductive toxicity, other endocrine effects and cancer; human epidemiology, and exposure studies; residues appearing in remote areas of the worl...
متن کاملDetermination of endocrine-disrupting pesticides and polychlorinated biphenyls in human serum by GC-ECD and GC-MS-MS and evaluation of contributions to the uncertainty of the results.
The chemicals endosulfan-alpha, endosulfan-beta, endosulfan sulfate, endosulfan ether, endosulfan lactone, PCB-21, PCB-48, PCB-61, and PCB-136 have been determined in 100 serum samples from women living in agricultural areas of Almería (Spain). The study includes a surgically treated breast cancer patient and a matching group of women with no sign of estrogenic-dependent disease. The determinat...
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